general tests fpgee practice test

Foreign Pharmacy Graduate Equivalency Examination

Last exam update: Nov 18 ,2025
Page 1 out of 29. Viewing questions 1-15 out of 426

Question 1

In a zero order elimination process, which of the following is true?

  • A. The removal of drug is independent of drug concentration
  • B. Cl = Elimination rate/Cp
  • C. t1/2 = .7VD/Cl
  • D. All are true
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Answer:

A

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Question 2

For highly polar drugs (e.g. mannitol) what primarily determines elimination rate?

  • A. Excretion rate
  • B. Metabolism rate
  • C. Absorption rate
  • D. Distribution rate
  • E. All of the above
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Answer:

A

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Question 3

Bioavailability is related to which of the following parameters, according to the equation F = 1 - E

  • A. Excretion
  • B. Elimination
  • C. Extraction Ratio
  • D. Enterohepatic Recycling
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Answer:

C

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Question 4

For the majority of drugs, which of the following equations correctly defines clearance?

  • A. Cl = Elimination rate/Cp
  • B. Cl = QxE
  • C. Cl = .7VD/t1/2
  • D. All are correct
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Answer:

D

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Question 5

How much of a 10 mg dose of morphine reaches the systemic circulation given F = .24?

  • A. 24mg
  • B. 0.24 mg
  • C. 2.4 mg
  • D. 4.1 mg
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Answer:

C

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Question 6

Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70 Kg for morphine, approximately how much of a
10 mg IV dose remains after 8 hr, given to a normal 70 Kg patient?

  • A. 5 mg
  • B. 2.5 mg
  • C. 1.25 mg
  • D. 625 mg
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Answer:

C

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Question 7

Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal
hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given
in the previous question is entirely hepatic clearance.

  • A. 30 L/hr/70 Kg
  • B. 60 L/hr/70 Kg
  • C. 120 L/hr/70 Kg
  • D. 250 L/hr/70 Kg
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A

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Question 8

Which of the following enzymes could directly act on codeine?

  • A. Glucuronyl transferase
  • B. Sulfotransferase
  • C. Glutathione transferase
  • D. A & B
  • E. All of the above
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Answer:

D

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Question 9

Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?

  • A. CYP1A2
  • B. CYP2C9
  • C. CYP3A4
  • D. CYP51
  • E. All are drug metabolizing isoforms
Mark Question:
Answer:

D

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Question 10

Which of the following Cytochrome P450 isozymes is responsible for the bulk of phase I metabolism?

  • A. CYP1A2
  • B. CYP2C9
  • C. CYP2D6
  • D. CYP3A4
  • E. CYP51
Mark Question:
Answer:

E

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Question 11

Which of the following enzymes could metabolize ethanol?

  • A. Cytochrome P450
  • B. Alcohol Dehydrogenase
  • C. Glucuronyl Transferase
  • D. Sulfotransferase
  • E. All of the above
Mark Question:
Answer:

E

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Question 12

Which of the following are similarities between Cytochrome P450 and MAO?

  • A. Both add oxygen from O2 to substrates and also form water
  • B. Both carry out direct heteroatom oxidations
  • C. Both carry out oxidative deaminations
  • D. Both carry out N-dealkylations
  • E. All of the above
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Answer:

C

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Question 13

What would be the preferred route of metabolism of succinyl choline?

  • A. Ester hydrolysis
  • B. N-oxidation
  • C. Glucuronide conjugation
  • D. A & B
  • E. All of the above
Mark Question:
Answer:

C

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Question 14

Which of the following causes the smallest change in solubility?

  • A. Hydroxylation
  • B. Glucuronidation
  • C. Sulfation
  • D. Glutathione conjugation
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Answer:

A

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Question 15

Cigarette smoke causes an increase in levels of CYP1A isozymes. Theophylline is primarily
metabolized by the CYP1A system. What would happen to theophylline clearance for an asthmatic
patient in hospital who could not smoke?

  • A. No change
  • B. Increase
  • C. Decrease
Mark Question:
Answer:

C

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